5-METHOXYISOPHTHALIC ACID
5-Methoxyisophthalic acid
CAS: 46331-50-4
Molecular Formula: C9H8O5
5-METHOXYISOPHTHALIC ACID - Names and Identifiers
5-METHOXYISOPHTHALIC ACID - Physico-chemical Properties
| Molecular Formula | C9H8O5 |
| Molar Mass | 196.16 |
| Density | 1.416±0.06 g/cm3(Predicted) |
| Melting Point | 275-280 °C (lit.) |
| Boling Point | 270 °C |
| Solubility | DMSO, Methanol |
| Appearance | Solid |
| Color | Off-White |
| pKa | 3.41±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00272364 |
5-METHOXYISOPHTHALIC ACID - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29189900 |
5-METHOXYISOPHTHALIC ACID - Reference Information
| Use | 5-methoxyisophthalic acid is a degradation product of humic acid found in soil. 5-Methoxyisophthalic acid is also used to synthesize homologs of several achiral compounds. It is a common pharmaceutical and chemical intermediate. |
| Preparation | 5-methoxy-isophthalaldehyde can be synthesized from 5-methoxy-1, 3-phenylene dimethanol, and further oxidation to obtain 5-methoxyisophthalic acid; 5-methoxy-isophthalic acid is prepared by hydrolysis reaction; it can also be prepared by 5-hydroxyisophthalic acid through methanol to ether reaction [1]. The preparation reaction formula of 5-methoxy isophthalic acid is as follows: The preparation reaction method of 5-methoxy isophthalic acid 1. take a single-port reaction bottle, weigh 5-methoxy-iso-phthalic acid Dimethyl ester is dissolved in tetrahydrofuran solution, the stirring device is started, 1N hydrochloric acid aqueous solution is added dropwise, after the feeding is completed, the system is clarified, the reaction is stirred at room temperature for 4 hours, and the reaction progress is detected by thin layer chromatography. After the reaction is completed, spin the dry reaction liquid, the concentrate is recrystallized with acetone, white solids are precipitated, the solids are filtered, the filter cake is washed with ethyl acetate, and the filter cake is dried to obtain a white solid, namely 5-methoxy isophthalic acid. Methods Take a three-port reaction bottle 2., prepare a reflux device and a feeding funnel, weigh 5-hydroxyisophthalic acid and dissolve it in 180mL methanol, place it in a three-port reaction bottle, start the stirring device, add concentrated hydrochloric acid dropwise, after the feeding is completed, the system is clarified, the solution is heated to reflux reaction, the reflux reaction continues for 4 hours, and the reaction progress is detected by thin layer chromatography. After the reaction is completed, remove the oil bath, after the reaction liquid is cooled, spin the reaction liquid, the concentrate is recrystallized with acetone, white solids are precipitated, the solids are filtered, the filter cake is washed with ethyl acetate, and the filter cake is dried to obtain a white solid, namely 5-Methoxy isophthalic acid. |
Last Update：2024-04-09 02:00:08
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